Senior Remote Python Jobs Paying $50K+ (12 open)

There are 12 senior Remote Python Jobs Paying $50K+ on CafeRemote right now, newest first. These roles were matched to Python by the skills and category each employer listed, not by keyword guessing. Most of these remote jobs hire from the United States, Canada and the United Kingdom; the rest are open worldwide. Applications go directly to the employer; CafeRemote never sits between you and the hiring team.